For immunochemical analysis of cRBP7
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Cellular Retinol Binding Protein 7 Polyclonal Antibody

Item No. 10010250

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cellular Retinol Acid-Binding Protein IV
  • cRBP7
  • RET7
  • Retinoid Binding Protein 7
Immunogen
Synthetic peptide from human cRBP7 amino acids 125-134 (QVCKQTFQRA)
Formulation (Request formulation change)
Peptide affinity-purified IgG
Host
Rabbit
Applications
WB and IHC
Species Reactivity
(+) Human cRBP(+) African Green Monkey cRBP(+) Mouse cRBP(+) Rat cRBP
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Retinol is an essential micronutrient that plays a critical role in various physiological functions including cell growth and differentiation. Due to the instability and low solubility of retinol in the aqueous medium, it requires specific binding proteins in body fluids and within the cell for transport.1 Cytoplasmic carriers of the retinol molecule, the cellular retinol-binding proteins (CRBPs), are monomeric proteins of about 15 kDa. cRBP7 is the most recently indentified cellular retinol carrier found to be expressed mainly in the kidney, heart, and transverse colon in humans.2 In addition to the intracellular transport role of cRBR7, further study of this protein is warranted. Cayman's cRBP7 polyclonal antibody detects both the mature protein at about 15 kDa by western blot in tissues/cells such as heart, HEK 293 cells, COS-7 cells, and RAW 264.7 cells. The antibody can also be used for immunocytochemistry.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Noy, N. Retinoid-binding proteins: Mediators of retinoid action. Biochem. J. 348(Pt. 3), 481-495 (2000).

    2. Folli, C., Calderone, V., Ramazzina, I., et al. Ligand binding and structural analysis of a human putative cellular retinol-binding protein. The Journal of Biological Chemisty 277(44), 41970-41977 (2002).