A nitric oxide synthase inhibitor
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Methyl-L-NIO (hydrochloride)

Item No. 10010252

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-(1-iminopropyl)-L-ornithine, monohydrochloride
CAS Number
150403-96-6
Molecular Formula
C8H17N3O2 • HCl
Formula Weight
223.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
CCC(NCCC[C@H](N)C(O)=O)=N.Cl
InChi Code
InChI=1S/C8H17N3O2.ClH/c1-2-7(10)11-5-3-4-6(9)8(12)13;/h6H,2-5,9H2,1H3,(H2,10,11)(H,12,13);1H
InChi Key
FADRJPGCWHNIBW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $71

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    10 mg

    $131

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    25 mg

    $308

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    50 mg

    $547

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    Product Description

    Methyl-L-NIO (hydrochloride) is a competitive nitric oxide synthase (NOS) inhibitor that competes with L-arginine for the amino acid binding site. It is a more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Babu, B.R., and Griffith, O.W. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. The Journal of Biological Chemisty 273(15), 8882-8889 (1998).