A lysophosphatidic acid analog
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1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)

Item No. 10010291

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate, monosodium salt
Synonyms
  • LPA O-18:0
  • O-18:0 LPA
  • 1-Octadecyl-2-hydroxy-sn-glycero-3-PA
  • 1-Octadecyl LPA
  • 1-Octadecyl Lysophosphatidic Acid
  • 1-Oleyl LPA
  • 1-Oleyl Lysophosphatidic Acid
  • PA(O-18:0/0:0)
  • 1-Stearyl-2-hydroxy-sn-glycero-3-PA
Molecular Formula
C21H44O6P • Na
Formula Weight
446.5
Purity
≥95%
Formulation
A crystalline solid
SMILES
O[C@@H](COP([O-])(O)=O)COCCCCCCCCCCCCCCCCCC.[Na+]
InChi Code
InChI=1S/C21H45O6P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26-19-21(22)20-27-28(23,24)25;/h21-22H,2-20H2,1H3,(H2,23,24,25);/q;+1/p-1/t21-;/m1./s1
InChi Key
FYSJNCTWZSVDDQ-ZMBIFBSDSA-M
Side Chain Carbon Sum
18:0
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate (1-Octadecyl LPA) is a LPA analog containing stearyl alcohol at the sn-1 position. LPA binds to one of five different G protein-linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.1,2 Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA receptor. For example, 1-octadecyl LPA has platelet aggregating activity with an EC50 value of 9 nM versus an EC50 value of 177 nM for 1-octadecanoyl LPA.3

    WARNING This product is not for human or veterinary use.