An S1P1 agonist
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KRP 203

Item No. 10010426

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-1,3-propanediol, monohydrochloride
CAS Number
509088-69-1
Synonyms
  • Mocravimod (hydrochloride)
Molecular Formula
C24H26ClNO3S • HCl
Formula Weight
480.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 15 mg/ml
SMILES
Cl.OCC(N)(CO)CCc1ccc(Sc2cccc(Oc3ccccc3)c2)cc1Cl
InChi Code
InChI=1S/C23H24ClNO3S.ClH/c24-22-14-21(10-9-17(22)11-12-23(25,15-26)16-27)29-20-8-4-7-19(13-20)28-18-5-2-1-3-6-18;/h1-10,13-14,26-27H,11-12,15-16,25H2;1H
InChi Key
HBJMPJWEMFBTMU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $385

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    Product Description

    KRP 203 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist.1 It selectively induces calcium mobilization in CHO-K1 cells expressing mouse S1P1 over mouse S1P3 and S1P4 (EC50s = 0.84, >1,000, and 9.61 nM, respectively). In vivo, KRP 203 (0.3 mg/kg) prevents the development of wasting syndrome, decreases diarrhea and colonic inflammatory cell infiltration, and increases colon length in an IL10-/- mouse model of colitis. KRP 203 inhibits inflammatory cell infiltration and prolongs allograft survival in a rat model of minor histocompatibility complex-disparate heart transplantation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Song, J., Matsuda, C., Kai, Y., et al. A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-deficient mice. J. Pharmacol. Exp. Ther. 324(1), 276-283 (2007).

    2. Shimizu, H., Takahashi, M., Kaneko, T., et al. KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts. Circulation 111(2), 222-229 (2005).