Novel ω-6 dienoic PUFA
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Product Categories

Product Type

Biochemicals
Lipids
Fatty Acids

Research Area

Lipid Biochemistry
Fatty Acids

5(Z),14(Z)-Eicosadienoic Acid

Item No. 10010484

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5Z,14Z-eicosadienoic acid
CAS Number
122055-58-7
Synonyms
  • FA 20:2
Molecular Formula
C20H36O2
Formula Weight
308.5
Purity
≥90%
Formulation (Request formulation change)
A 1 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 0.5 mg/ml
SMILES
CCCCC/C=C\CCCCCCC/C=C\CCCC(=O)O
InChi Code
InChI=1S/C20H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,15-16H,2-5,8-14,17-19H2,1H3,(H,21,22)/b7-6-,16-15-
InChi Key
ZPYAEYLYGOTGGC-OYAITDOQSA-N
Side Chain Carbon Sum
20:2
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $94

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    500 µg

    $412

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    1 mg

    $728

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    Product Description

    5(Z),14(Z)-Eicosadienoic Acid is a novel ω-6 C20:2 fatty acid. The more common 11(Z),14(Z)-eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki = 3.1 µM)1 and inhibits the binding of LTB4 to its receptor on neutrophils (Ki = 3.0 µM).2 Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.3 Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators. The physiological effects of 5(Z),14(Z)-eicosadienoic acid are unstudied.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mizushina, Y., Dairaku, I., Yanaka, N., et al. Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase. Biochimie 89(5), 581-590 (2007).

    2. Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukot. Essent. Fatty Acids 52(5), 293-297 (1995).

    3. Irmisch, G., Schläfke, D., Gierow, W., et al. Fatty acids and sleep in depressed inpatients. Prostaglandins, Leukot. Essent. Fatty Acids 76(1), 1-7 (2007).