A ClC-2 activator
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Lubiprostone

Item No. 10010487

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
16,16-difluoro-11α-hydroxy-9,15-dioxo-prostan-1-oic acid
CAS Number
136790-76-6
Synonyms
  • RU-0211
  • SPI-0211
Molecular Formula
C20H32F2O5
Formula Weight
390.5
Purity
≥95%
Formulation
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlEthanol: 10 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
SMILES
O=C1[C@H](CCCCCCC(O)=O)[C@@H]2[C@H](OC(O)C(C(F)(F)CCCC)C2)C1
InChi Code
InChI=1S/C20H32F2O5/c1-2-3-10-20(21,22)15-11-14-13(8-6-4-5-7-9-18(24)25)16(23)12-17(14)27-19(15)26/h13-15,17,19,26H,2-12H2,1H3,(H,24,25)/t13-,14-,15?,17-,19?/m1/s1
InChi Key
UFMXVXDWWQKSHH-HORNASKESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $69

    Add

    10 mg

    $115

    Add

    25 mg

    $198

    Add

    50 mg

    $329

    Add
    Product Description

    Lubiprostone is an activator of chloride channel protein 2 (ClC-2) and a bicyclic derivative of prostaglandin E1 (PGE1; Item No. 13010).1 It induces chloride currents in HEK293 cells expressing recombinant human ClC-2 (EC50 = ~17 nM), but not CFTR, chloride channels.2 Lubiprostone (1 µM) induces short-circuit currents, a marker of transepithelial chloride transport, in T84 intestinal cells. Lubiprostone (48 µg/animal, p.o.) increases postprandial antral contractions and decreases postprandial small bowel transit time in dogs.3 Formulations containing lubiprostone have been used in the treatment of irritable bowel syndrome with constipation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lacy, B.E., and Levy, L.C. Lubiprostone: A chloride channel activator. J. Clin. Gastroenterol. 41(4), 345-351 (2007).

    2. Cuppoletti, J., Malinowska, D.H., Tewari, K.P., et al. SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am. J. Physiol. Cell Physiol. 287, C1173-C1183 (2004).

    3. Song, J., Yin, J., Xu, X., et al. Prokinetic effects of large-dose lubiprostone on gastrointestinal transit in dogs and its mechanisms. Am. J. Transl. Res. 7(3), 513-521 (2015).