An 2,3-Oxidosqualene cyclase inhibitor
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BIBB 515

Item No. 10010517

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4-chlorophenyl)[4-[[4-(4,5-dihydro-2-oxazolyl)phenyl]methylene]-1-piperidinyl]-methanone
CAS Number
156635-05-1
Molecular Formula
C22H21ClN2O2
Formula Weight
380.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.30 mg/mlDMSO: 0.25 mg/mlEthanol: 0.15 mg/ml
λmax
276 nm
SMILES
Clc1ccc(cc1)C(=O)N1CCC(=Cc2ccc(cc2)C2=NCCO2)CC1
InChi Code
InChI=1S/C22H21ClN2O2/c23-20-7-5-19(6-8-20)22(26)25-12-9-17(10-13-25)15-16-1-3-18(4-2-16)21-24-11-14-27-21/h1-8,15H,9-14H2
InChi Key
JQNWPWUJMRAASQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $49

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    10 mg

    $82

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    50 mg

    $329

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    100 mg

    $516

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    Product Description

    2,3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. OSC catalyzes the conversion of (3S)-2,3-oxidosqualene to lanosterol, a precursor to cholesterol, in mammals and fungi. BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. Total cholesterol was reduced by 19% in normolipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eisele, B., Budzinski, R., Müller, P., et al. Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. J. Lipid Res. 38(3), 564-574 (1997).