Inhibitor of reticulocyte 15-lipoxygenase-1
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PD 146176

Item No. 10010518

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,11-dihydro-[1]benzothiopyrano[4,3-b]indole
CAS Number
4079-26-9
Synonyms
  • NSC 168807
Molecular Formula
C15H11NS
Formula Weight
237.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:5): 0.15 mg/mlDMSO: 10 mg/mlEthanol: 2 mg/ml
SMILES
c1ccc2c(c1)SCc1c2[nH]c2ccccc12
InChi Code
InChI=1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2
InChi Key
ZGOOPZVQMLHPFM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $53

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    10 mg

    $98

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    25 mg

    $231

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    50 mg

    $409

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    Product Description

    PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1.1 It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits and reduces oxidant stress-induced apoptosis in endothelial cells.1,2,3 PD 146176 inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP.4 In addition, it lacks significant non-specific antioxidant properties.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bocan, T.M.A., Rosebury, W.S., Mueller, S.B., et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. Atherosclerosis 136, 203-216 (1998).

    2. Sendobry, S.M., Cornicelli, J.A., Welch, K., et al. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br. J. Pharmacol. 120, 1199-1206 (1997).

    3. Sordillo, L.M., Weaver, J.A., Cao, Y.Z., et al. Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. Prostaglandins Other Lipid Mediat. 76, 19-34 (2005).

    4. Succol, F., and Praticò, D. A role for 12/15 lipoxygenase in the amyloid ß precursor protein metabolism. J. Neurochem. 103, 380-387 (2007).

    Product Citations

    Soriano-Castell, D., Currais, A., and Maher, P. Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis. Free Radic. Biol. Med. S0891-5849(21), (2021).

    Shah, R., Farmer, L.A., Zilka, O., et al. Beyond DPPH: Use of fluorescence-enabled inhibited autoxidation to predict oxidative cell death rescue. Cell Chem. Biol. 26(11), 1594-1607 (2019).

    Conrad, M., and Pratt, D.A. The chemical basis of ferroptosis. Nat. Chem. Biol. 15(12), 1137-1147 (2019).

    Archambault, A.-S., Turcotte, C., Martin, C., et al. Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils. PLoS One 13(8), e0202424 (2018).