An anticoagulant and vitamin K antagonist
Related Products
Labeled Version(s)
35477Acenocoumarol-d4
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Acenocoumarol

Item No. 10010569

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one
CAS Number
152-72-7
Synonyms
  • (±)-Acenocoumarin
  • (±)-Nicoumalone
  • G-23350
Molecular Formula
C19H15NO6
Formula Weight
353.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 10 mg/mlEthanol: 0.2 mg/ml
λmax
283 nm
SMILES
CC(=O)CC(c1ccc(cc1)[N+](=O)[O-])c1c(=O)oc2ccccc2c1O
InChi Code
InChI=1S/C19H15NO6/c1-11(21)10-15(12-6-8-13(9-7-12)20(24)25)17-18(22)14-4-2-3-5-16(14)26-19(17)23/h2-9,15,22H,10H2,1H3
InChi Key
VABCILAOYCMVPS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $63

    Add

    25 mg

    $146

    Add

    50 mg

    $274

    Add

    100 mg

    $481

    Add
    Product Description

    Acenocoumarol is an anticoagulant and vitamin K antagonist.1 It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase (VKOR) (IC50 = 1.5 and 5.8 nM for VKORC1 and VKORC1L1, respectively).1 Acenocoumarol also inhibits a variety of VKOR mutants in cell-based reporter assays (IC50s = 0.54-11.21 nM).2 It prolongs prothrombin time in rat blood when administered at a dose of 1.5 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Czogalla, K.J., Liphardt, K., Höning, K., et al. VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites. Blood Adv. 2(6), 691-702 (2018).

    2. Chen, X., Jin, D.-Y., Stafford, D.W., et al. Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu. Blood 132(18), 1974-1984 (2018).

    3. Meinertz, T., Kasper, W., Kahl, C., et al. Anticoagulant activity of the enantiomers of acenocoumarol. Br. J. Clin. Pharmacol. 5(2), 187-188 (1978).