An affinity probe for linoleic acid binding proteins
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Linoleic Acid-biotin

Item No. 10010623

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9Z,12Z-octadecadienoyl-N’-biotinoyl-1,5-diaminopentane
Molecular Formula
C28H48N4O3S
Formula Weight
520.8
Purity
≥95%
Formulation (Request formulation change)
A 1 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
0.1 M Na2CO3: 0.5 mg/mlDMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/ml
SMILES
CCCCC/C=C\C/C=C\CCCCCCCC(=O)NCCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12
InChi Code
InChI=1S/C33H58N4O3S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17-23-30(38)34-25-20-16-21-26-35-31(39)24-19-18-22-29-32-28(27-41-29)36-33(40)37-32/h6-7,9-10,28-29,32H,2-5,8,11-27H2,1H3,(H,34,38)(H,35,39)(H2,36,37,40)/b7-6-,10-9-/t28-,29+,32-/m0/s1
InChi Key
TXYWCIYPXRNWJU-IWHQMKILSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µg

    $63

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    500 µg

    $274

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    1 mg

    $481

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    Product Description

    Linoleic acid is an essential fatty acid and one of the most abundant polyunsaturated fatty acids (PUFAs) in the western diet. Deficiencies in linoleic acid are linked to defective wound healing, growth retardation, and dermatitis.1,2 Linoleic acid is metabolized by 15-LO in both plants and animals to form 9- and 13-HODE.3 Linoleic acid-biotin was designed to allow linoleic acid to be detected in complexes with protein-binding partners such as fatty acid binding proteins (FABPs). Biotinylated lipids have been used to capture lipid-associated proteins in the study of lipid signaling and transport.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Søyland, E., Fund, J., Rajka, G., et al. Effect of dietary supplementation with very-long-chain n-3 fatty acids in patients with psoriasis. N. Engl. J. Med. 328(25), 1812-1816 (1993).

    2. Hashimoto, A., Katagiri, M., Torii, S., et al. Effect of the dietary α-linolenate/linoleate balance on leukotriene production and histamine release in rats. Prostaglandins 36(1), 3-16 (1988).

    3. Vick, B.A. Oxygenated fatty acids of the lipoxygenase pathway. Lipid Metabolism in Plants 167-191 (1993).

    4. Brock, T.G. Capturing proteins that bind polyunsaturated fatty acids: Demonstration using arachidonic acid and eicosanoids. Lipids 43(2), 161-169 (2008).