An irreversible inhibitor of H2S synthesis
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DL-Propargyl Glycine (hydrochloride)

Item No. 10010948

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-4-pentynoic acid, monohydrochloride
CAS Number
16900-57-5
Synonyms
  • PAG
Molecular Formula
C5H7NO2 • HCl
Formula Weight
149.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
NC(C(O)=O)CC#C.Cl
InChi Code
InChI=1S/C5H7NO2.ClH/c1-2-3-4(6)5(7)8;/h1,4H,3,6H2,(H,7,8);1H
InChi Key
UAMBUICGODABQY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $19

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    5 mg

    $74

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    10 mg

    $130

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    50 mg

    $561

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    Cayman Chemical
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    Product Description

    Hydrogen sulphide (H2S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator.1 DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H2S synthesis activity in rat liver preparations with an IC50 value of 55 µM and abolishes the rise in plasma H2S in anaesthetized rats induced with hemorrhagic shock.2 At concentrations ranging from 25-100 mg/kg, PAG can reduce H2S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, L., and Moore, P.K. Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air? Trends Pharamacol. Sci. 29(2), 84-90 (2007).

    2. Mok, Y.Y.P., Atan, M.S.B.M., Ping, C.Y., et al. Role of hydrogen sulphide in haemorrhagic shock in the rat: Protective effect of inhibitors of hydrogen sulphide biosynthesis. Br. J. Pharmacol. 143(7), 881-889 (2004).

    3. Bhatia, M., Sidhapuriwala, J.N., Ng, S.W., et al. Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis. J. Cell. Mol. Med. 12(2), 580-590 (2008).

    4. Bhatia, M., Sidhapuriwala, J., Moochhala, S.M., et al. Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat. Br. J. Pharmacol. 145, 141-144 (2005).

    5. Collin, M., Anuar, F.B.M., Murch, O., et al. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. Br. J. Pharmacol. 146, 498-505 (2005).