A vitamin K2 analog
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Menaquinone 7

Item No. 10011051

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaen-1-yl]-3-methyl-1,4-naphthalenedione
CAS Number
2124-57-4
Synonyms
  • MK-7
  • Vitamin K2(35)
  • Vitamin MK-7
Molecular Formula
C46H64O2
Formula Weight
649.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
248, 270, 330 nm
SMILES
O=C(C(C)=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)\C)C1=O)C2=C1C=CC=C2
InChi Code
InChI=1S/C46H64O2/c1-34(2)18-12-19-35(3)20-13-21-36(4)22-14-23-37(5)24-15-25-38(6)26-16-27-39(7)28-17-29-40(8)32-33-42-41(9)45(47)43-30-10-11-31-44(43)46(42)48/h10-11,18,20,22,24,26,28,30-32H,12-17,19,21,23,25,27,29,33H2,1-9H3/b35-20+,36-22+,37-24+,3
InChi Key
RAKQPZMEYJZGPI-LJWNYQGCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $134

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    5 mg

    $530

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    10 mg

    $926

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    Product Description

    Menaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods.1 It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 µM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats.2 In vivo, MK-7 (100 µg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification.3 It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Katsuyama, H., Otsuki, T., Tomita, M., et al. Menaquinone-7 regulates the expressions of osteocalcin, OPG, RANKL and RANK in osteoblastic MC3T3E1 cells. Int. J. Mol. Med. 15(2), 231-236 (2005).

    2. Ehara, Y., Takahashi, H., Hanahisa, Y., et al. Effect of vitamin K2 (menaquinone-7) on bone metabolism in the femoral-metaphyseal tissues of normal and skeletal-unloaded rats: Enhancement with zinc. Res. Exp. Med. (Berl.) 196(3), 171-178 (1996).

    3. Scheiber, D., Veulemans, V., Horn, P., et al. High-dose menaquinone-7 supplementation reduces cardiovascular calcification in a murine model of extraosseous calcification. Nutrients 7(8), 6991-7011 (2015).

    4. Wu, W.-J., Lee, H.-Y., Lee, G.-H., et al. The antiosteoporotic effects of Cheonggukjang containing vitamin K2 (menaquinone-7) in ovariectomized rats. J. Med. Food 17(12), 1298-1305 (2014).