A ribonucleotide reductase inhibitor
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Alternative(s)
10009083Trimidox
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Trimidox (hydrochloride)

Item No. 10011124

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,3,4,5-tetrahydroxy-benzenecarboximidamide, monohydrochloride
CAS Number
95933-75-8
Synonyms
  • CF 233
Molecular Formula
C7H8N2O4 • HCl
Formula Weight
220.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 2 mg/mlEthanol: 0.25 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
220, 280 nm
SMILES
Cl.ONC(=N)c1cc(O)c(O)c(O)c1
InChi Code
InChI=1S/C7H8N2O4.ClH/c8-7(9-13)3-1-4(10)6(12)5(11)2-3;/h1-2,10-13H,(H2,8,9);1H
InChi Key
KBKNXSNOQYLIRI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $71

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    10 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.1 Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.1,2 Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Szekeres, T., Fritizer, M., Strobl, H., et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Blood 84(12), 4316-4321 (1994).

    2. Kanno, S.I., Uwai, K., Tomizawa, A., et al. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells. Basic Clin. Pharmacol. Toxicol. 98(1), 44-50 (2006).