For immunochemical analysis of p38 MAPK
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

p38 MAPK Monoclonal Antibody (Clone 9F12)

Item No. 10011301

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • p38 MAPKα
  • p38 MAP Kinase
  • p38 Mitogen-activated Protein Kinase
Immunogen
human full length p38 MAPK
Clone Designation
9F12
Formulation (Request formulation change)
200 µg of affinity-purified monoclonal antibody
Storage Buffer
500 µl PBS, pH 7.4, with 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide
Host
Mouse
Isotype
IgG1
Applications
FC. ICC, WB
Species Reactivity
(+) Human p38 MAPK(+) Mouse p38 MAPK(+) Rat p38 MAPK
Origin
Animal/Mouse
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 ea (200 µg)

    $347

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    p38 mitogen-activated protein kinase (MAPK) is a member of the serine-threonine MAPK family that triggers many cellular processes including cell cycle, development, and apoptosis.1,2 These kinases are activated by environmental stress signals such as osmotic shock, infection, and cytokines causing phosphorylation of p38 MAPK. This results in a phosphorylation cascade, activating transcription factors, and inducing gene expression.1,3 p38 MAPK is widely expressed in heart, brain, skeletal muscle, platelets, and immune cells. Due to this distribution, p38 MAPK plays a role in cardiovascular disease, arthritis, and cancer.2,4,5,3 It is mainly present in the cytosol, but can also be found in the nucleus after activation.2 Based on the amino acid sequence, the expected molecular weight of this protein is 41 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Junttila, M.R., Li, S.P., and Westermarck, J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. The FASEB Journal 22, 1-12 (2008).

    2. Dhillon, A.S., Hagan, S., Rath, S., et al. MAP kinase signalling pathways in cancer. Oncogene 26, 3279-3290 (2007).

    3. Wang, Y. Mitogen-activated protein kinases in heart development and diseases. Circulation 116, 1413-1423 (2007).

    4. Schett, G., Zwerina, J., and Firestein, G. The p38 mitogen activated protein kinase (MAPK) pathway in rheumatoid arthritis. Ann. Rheum. Dis. 67, 909-916 (2007).

    5. Foster, A., Fitzsimmons, B., Rokach, J., et al. Evidence of in vivo ω-oxidation of peptide leukotrienes in the rat: Biliary excretion of 20-CO2H N-acetyl LTE4. Biochem. Biophys. Res. Commun. 148, 1237-1245 (1987).