An OAT inhibitor
Related Products
Isomer(s)
36916Isosteviol
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Steviol

Item No. 10011344

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4α)-13-hydroxy-kaur-16-en-18-oic acid
CAS Number
471-80-7
Synonyms
  • Hydroxy Dehydrostevic Acid
  • NSC 226902
Molecular Formula
C20H30O3
Formula Weight
318.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 25 mg/mLEthanol: 30 mg/mLEthanol:PBS(pH 7.2) (1:1): 0.5 mg/mL
SMILES
C=C1[C@@]2(O)C[C@]3(C1)CC[C@]4([H])[C@](C)(C(O)=O)CCC[C@@]4(C)[C@]3([H])CC2
InChi Code
InChI=1S/C20H30O3/c1-13-11-19-9-5-14-17(2,7-4-8-18(14,3)16(21)22)15(19)6-10-20(13,23)12-19/h14-15,23H,1,4-12H2,2-3H3,(H,21,22)/t14-,15-,17+,18?,19+,20-/m0/s1
InChi Key
QFVOYBUQQBFCRH-IBYIWXLNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $178

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    25 mg

    $392

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    50 mg

    $739

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    Product Description

    Steviol is the aglycon derivative of steviol glycosides, which are natural sweeteners isolated from S. rebaudiana. Steviol inhibits human organic anion transporters (hOATs) in uptake assays using murine cells from the S2 segment of proximal tubules. It is selective for hOAT1 and hOAT3 over hOAT2 and hOAT4 (IC50s = 11.4, 36.5, 1,000, and 285 μM, respectively).1 Uptake assays in mouse renal cortical slices yield similar results with IC50 values of 12.8 and 67.6 μM for hOAT1 and hOAT3, respectively.1 Due to the use of steviol glycosides as sweeteners, the safety of steviol is widely studied, including its genotoxicity and toxicokinetics.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Srimaroeng, C., Jutabha, P., Pritchard, J.B., et al. Interactions of stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal cortical slices. Pharm Res. 22(6), 858-866 (2005).

    2. Brusick, D.J. A critical review of the genetic toxicity of steviol and steviol glycosides. Food Chem. Toxicol. 46(Suppl 7), S83-S91 (2008).

    3. Roberts, A., and Renwick, A.G. Comparative toxicokinetics and metabolism of rebaudioside A, stevioside, and steviol in rats. Food Chem. Toxicol. 46(Suppl 7), S31-S39 (2008).