Precursor for palmitoyl ethanolamide
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Glycerophospho-N-Palmitoyl Ethanolamine

Item No. 10011356

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
mono(2,3-dihydroxypropyl)-mono[2-[(1-oxohexadecyl)amino]ethyl]ester phosphoric acid
CAS Number
100575-09-5
Synonyms
  • GP-NAE
  • GP-NPEA
Molecular Formula
C21H44NO7P
Formula Weight
453.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 5 mg/ml
SMILES
CCCCCCCCCCCCCCCC(=O)NCCOP(=O)(O)OCC(O)CO
InChi Code
InChI=1S/C21H44NO7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-21(25)22-16-17-28-30(26,27)29-19-20(24)18-23/h20,23-24H,2-19H2,1H3,(H,22,25)(H,26,27)
InChi Key
FIXMIXZULLAMCB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $193

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    5 mg

    $819

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    Product Description

    Glycerophospho-N-palmitoyl ethanolamine (GP-NPEA) is the metabolic precursor of palmitoyl ethanolamide (PEA). PEA is an endogenous cannabinoid found in brain, liver, and other mammalian tissues,1 that has potent anti-inflammatory activity in vivo.2 PEA has low affinity for peripheral cannabinoid (CB2) and no appreciable affinity for central cannabinoid (CB1),3 suggesting that its efficacy is through a different receptor.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. The Journal of Biological Chemisty 240, 1019-1024 (1965).

    2. Wise, L.E., Cannavacciulo, R., Cravatt, B.F., et al. Evaluation of fatty acid amides in the carrageenan-induced paw edema model. Neuropharmacology 54(1), 181-188 (2008).

    3. Devane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258(5090), 1946-1949 (1992).