A derivative of phytanic acid
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phytanoyl-Coenzyme A (triethylammonium salt)

Item No. 10011499

Technical Information
Formal Name
(3,7,11,15-tetramethylhexadecanoate)-coenzyme A, triethylammonium salt
Synonyms
  • Phytanic Acid Coenzyme A Ester (triethylammonium salt)
  • phytanoyl-CoA (triethylammonium salt)
Molecular Formula
C41H74N7O17P3S • 3C6H15N
Formula Weight
Purity
≥95%
A crystalline solid
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 0.5 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
259 nm
SMILES
CC(C)CCCC(C)CCCC(C)CCCC(C)CC(SCCNC(CCNC([C@@](O)([H])C(C)(C)COP(OP([O-])(OCC1C(OP(O)([O-])=O)C(O)C(N2C=NC3=C2N=CN=C3N)O1)=O)([O-])=O)=O)=O)=O.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC
InChi Code
InChI=1S/C41H74N7O17P3S.3C6H15N/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48;3*1-4-7(5-
InChi Key
YPPWBXNCPGZYJL-LHSCBJDXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Phytanic acid is a saturated 20-carbon branched-chain fatty acid that can only be derived from dietary sources. Under normal conditions, phytanic acid is degraded via α-oxidation (oxidative decarboxylation) to produce pristanic acid, which then undergoes β-oxidation as part of the metabolism process.1,2 Degradation of phytanic acid is impaired in patients with peroxisomal disorders or diseases such as infantile phytanic acid storage disease or Refsum’s disease.3 phytanoyl-Coenzyme A (CoA) is the conjugate of phytanic acid and CoA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Watkins, P.A., Howard, A.E., and Mihalik, S.J. Phytanic acid must be activated to phytanoyl-CoA prior to its α-oxidation in rat liver peroxisomes. Biochim. Biophys. Acta 1214(3), 288-294 (1994).

    2. Watkins, P.A., Howard, A.E., Gould, S.J., et alPhytanic acid activation in rat liver peroxisomes is catalyzed by long-chain acyl-CoA synthetase. J. Lipid Res. 37(11), 2288-2295 (1996).

    3. Wanders, R.J.A., Boltshauser, E., Steinmann, B., et alInfantile phytanic acid storage disease, a disorder of peroxisome biogenesis: A case report. J. Neurol. Sci. 98(1), 1-11 (1990).