Vitamin E derivative with antioxidant properties
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Product Categories

Product Type

Biochemicals
Antioxidants

Research Area

Cancer
Cell Biology
Cell Death
Neuroscience

Trolox

Item No. 10011659

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
CAS Number
53188-07-1
Synonyms
  • 6-hydroxy-2,5,7,8-tetramethylchroman-2-Carboxylic Acid
Molecular Formula
C14H18O4
Formula Weight
250.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 3 mg/ml
λmax
291 nm
SMILES
Cc1c2OC(C)(CCc2c(C)c(O)c1C)C(=O)O
InChi Code
InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)
InChi Key
GLEVLJDDWXEYCO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    250 mg

    $43

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    500 mg

    $61

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    1 g

    $77

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    Cayman Chemical
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    Product Description

    Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays.1,2 In addition, trolox is used to assess the role of oxidative injury in processes like neuronal cell death and aging.3,4 Trolox is effective as adjunctive therapy in the treatment of certain cancers.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cos, P., Hermans, N., Calomme, M., et al. Comparative study of eight well-known polyphenolic antioxidants. J. Pharm. Pharmacol. 55(9), 1291-1297 (2003).

    2. Tadolini, B., Juliano, C., Piu, L., et al. Resveratrol inhibition of lipid peroxidation. Free Radic. Res. 33, 105-114 (2000).

    3. Jang, H.J., Hwang, S., Cho, K.Y., et al. Taxol induces oxidative neuronal cell death by enhancing the activity of NADPH oxidase in mouse cortical cultures. Neurosci. Lett. 443, 17-22 (2008).

    4. Benedetti, M.G., Foster, A.L., Vantipalli, M.C., et al. Compounds that confer thermal stress resistance and extended lifespan. Exp. Gerontol. 43, 882-891 (2008).

    5. Diaz, Z., Laurenzana, A., Mann, K.K., et al. Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity. Leukemia 21, 2117-2127 (2007).

    Product Citations

    Bailey, C.P., Figueroa, M., Gangadharan, A., et al. Scaffolding LSD1 inhibitors impair NK cell metabolism and cytotoxic function through depletion of glutathione. Front. Immunol. 11, 2196 (2020).

    Kremer, D.M., Nelson, B.S., Lin, L., et al. GOT1 inhibition primes pancreatic cancer for ferroptosis through the autophagic release of labile iron. bioRxiv (2020).

    Hajmousa, G., Vogelaar, P., Brouwer, L.A., et al. The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells. Biomaterials 119, 43-52 (2017).

    Morita, M., Naito, Y., Yoshikawa, T., et al. Plasma lipid oxidation induced by peroxynitrite, hypochlorite, lipoxygenase and peroxyl radicals and its inhibition by antioxidants as assessed by diphenyl-1-pyrenylphosphine. Redox Biol. 8, 127-135 (2016).