A potent, selective iNOS inhibitor
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Propenyl-L-NIO (hydrochloride)

Item No. 10011724

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-[(3E)-1-imino-3-pentenyl]-L-ornithine, monohydrochloride
Synonyms
  • ENIPO
Molecular Formula
C10H19N3O2 • HCl
Formula Weight
249.7
Purity
≥90%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMSO: 2 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
C/C=C/CC(=N)NCCC[C@H](N)C(=O)O
InChi Code
InChI=1S/C10H19N3O2.ClH/c1-2-3-6-9(12)13-7-4-5-8(11)10(14)15;/h2-3,8H,4-7,11H2,1H3,(H2,12,13)(H,14,15);1H/b3-2+;
InChi Key
CMMBMUQLXSZAKX-SQQVDAMQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $119

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    25 mg

    $279

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    50 mg

    $494

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    Product Description

    Propenyl-L-NIO (hydrochloride) (ENIPO) is a potent, selective inhibitor of iNOS. The Ki values for inhibition of iNOS, nNOS, and eNOS by ENIPO are 17, 10.3 and 58.2 µM, respectively, as determined using initial rate binding kinetics.1 However, ENIPO is a time-dependent inhibitor that, with longer incubations, demonstrates reversible tight binding inhibition that is selective for iNOS over nNOS or eNOS. This selectivity results from iNOS exhibiting a 4-fold faster binding and 10-fold slower dissociation with ENIPO compared to nNOS.1 Ki values for ENIPO binding to iNOS and nNOS are 0.56 and 6 µM, respectively.1 Accurate determination of the Ki value of ENIPO for eNOS has not been determined but is expected to be 50-fold less than iNOS.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bretscher, L.E., Li, H., Poulos, T.L., et al. Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines. The Journal of Biological Chemisty 278(47), 46789-46797 (2003).