A modestly selective NOS inhibitor
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Ethyl-L-NIO (hydrochloride)

Item No. 10012088

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-(1-iminobutyl)-L-ornithine, monohydrochloride
CAS Number
150403-97-7
Synonyms
  • L-N5-(1-Iminobutyl)ornithine
Molecular Formula
C9H19N3O2 • HCl
Formula Weight
237.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.3 mg/mlDMSO: 2 mg/mlEthanol: 2.5 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
CCCC(=N)NCCC[C@H](N)C(=O)OCl
InChi Code
InChI=1S/C9H19N3O2.ClH/c1-2-4-8(11)12-6-3-5-7(10)9(13)14;/h7H,2-6,10H2,1H3,(H2,11,12)(H,13,14);1H
InChi Key
DWNWLIPSWIUXRG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $61

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    10 mg

    $112

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    50 mg

    $462

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    100 mg

    $807

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    Product Description

    Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 µM, respectively, as determined using initial rate measurements.1 However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively).1 Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Babu, B.R., and Griffith, O.W. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. The Journal of Biological Chemisty 273(15), 8882-8889 (1998).