A selective BLT2 agonist
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CAY10583

Item No. 10012424

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4'-[[(1-oxopentyl)phenylamino]methyl]-[1,1'-biphenyl]-2-carboxylic acid
CAS Number
862891-27-8
Molecular Formula
C25H25NO3
Formula Weight
387.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 10 mg/mlEthanol: 0.25 mg/ml
SMILES
CCCCC(N(C1=CC=CC=C1)CC2=CC=C(C3=C(C(O)=O)C=CC=C3)C=C2)=O
InChi Code
InChI=1S/C25H25NO3/c1-2-3-13-24(27)26(21-9-5-4-6-10-21)18-19-14-16-20(17-15-19)22-11-7-8-12-23(22)25(28)29/h4-12,14-17H,2-3,13,18H2,1H3,(H,28,29)
InChi Key
IUJTVDNJFPZYBL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $68

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    10 mg

    $124

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    25 mg

    $291

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    50 mg

    $515

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    Product Description

    CAY10583 is a potent, selective full agonist for BLT2 with an EC50 value of 20 nM.1 It does not displace [3H]-leukotriene B4 (LTB4) binding to BLT1 at concentrations >1 µM and activates BLT2 at significantly lower concentrations than LTB4 (EC50 = 170 nM).1 CAY10583 dose dependently increases intracellular calcium stores and induces ERK phosphorylation in Chinese hamster ovary (CHO) cells expressing BLT2 with no effect on CHO cells expressing BLT1.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iizuka, Y., Yokomizo, T., Terawaki, K., et al. Characterization of a mouse second leukotriene B4 receptor, mBLT2. BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. The Journal of Biological Chemisty 280(26), 24816-24823 (2005).