A stable PGI2 analog with antithrombotic properties
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CG 4305

Item No. 10012447

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(E)-[(3aR,4S,5S,6aR)-4-[(1E,3R)-3-cyclohexyl-3-hydroxy-1-propen-1-yl]hexahydro-5-hydroxy-2(1H)-pentalenylidene]methyl]-benzoic acid
Molecular Formula
C25H32O4
Formula Weight
396.5
Purity
≥95%
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/mlEthanol: 3 mg/ml
λmax
230, 257 nm
SMILES
O[C@@H]([C@@H]1/C=C/[C@@H](O)C2CCCCC2)C[C@@H]([C@@H]1C/3)CC3=C/C4=CC=CC(C(O)=O)=C4
InChi Code
InChI=1S/C25H32O4/c26-23(18-6-2-1-3-7-18)10-9-21-22-14-17(13-20(22)15-24(21)27)11-16-5-4-8-19(12-16)25(28)29/h4-5,8-12,18,20-24,26-27H,1-3,6-7,13-15H2,(H,28,29)/b10-9+,17-11+/t20-,21+,22-,23+,24+/m0/s1
InChi Key
OINUMRGCICIETD-CGKNXJIZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µg

    $112

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    500 µg

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    1 mg

    $876

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    Product Description

    CG 4305 is a stable carbacyclic analog of PGI2 that inhibits ADP-induced platelet aggregation 25% at a concentration of 50 nM.1 Doses of 10 mg/kg (oral) or 1 mg/kg (intraduodenal) have been shown to prevent rabbit carotid artery thrombosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maurin, N. Influence on platelet activity and red cell fluidity of epoprostenol and two stable prostacyclin analogues in vitro. Arzneimittelforschung 36(8), 1180-1183 (1986).