For immunochemical detection of TP receptor
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TP Receptor (human) Polyclonal FITC Antibody

Item No. 10012559

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Thromboxane A2 Receptor
  • TXA2 Receptor
Immunogen
Synthetic peptide from the C-terminal region of human TP receptor
Formulation (Request formulation change)
100 µl of fluorescein-labeled, peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
FC
Species Reactivity
(+) African green monkey(+) Human(+) Mouse(+) Rat
UniProt Accession №
P21731
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (100 µl)

    $388

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    Product Description

    Thromboxane A2 (TXA2) is a potent vasoconstrictor and activator of platelet aggregation. The short half-life of TXA2 ensures local action whether generated by vascular endothelial cells or by platelets and confers physiologically beneficial or deleterious effects under inflammatory situations.1,2 TXA2 elicits its effects via a 7-transmembrane domain G protein-coupled receptor, the TP receptor.3 This receptor can also bind prostaglandin H2 and isoprostanes and was first cloned from human placenta and the platelet-like MEG-01 cell line.4,5 The TP receptor is highly expressed in platelets and is relatively less abundant in tissues such as lung, kidney, brain, spleen, thymus, monocytes, uterus, and placenta.6,7,8,9,10,11

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cadroy, Y., and Harker, L.A. Platelets, thrombosis, and antithrombotic therapies. Cardiovascular Pharmacology 3rd ed., 515-539 (1990).

    2. Dogné, J.M., de Leval, X., Benoit, P., et al. Therapeutic potential of thromboxane inhibitors in asthma. Expert Opin. Investig. Drugs 11(2), 1-8 (2003).

    3. Ellis, E.F., Oelz, O., Roberts, L.J., II, et al. Coronary arterial smooth muscle contraction by a substance released from platelets: Evidence that it is thromboxane A2. Science 193(4258), 1135-1137 (1976).

    4. Janssen, L.J., and Tazzeo, T. Involvement of TP and EP3 receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculature. J. Pharmacol. Exp. Ther. 301(3), 1060-1066 (2002).

    5. Armstrong, R.A. Platelet Prostanoid Receptors. Pharmacotherapy 72(3), 171-191 (1996).

    6. Namba, T., Sugimoto, Y., Hirata, M., et al. Mouse thromboxane A2 receptor: cDNA cloning, expression and Northern blot analysis. Biochem. Biophys. Res. Commun. 184(3), 1197-1203 (1992).

    7. Båtshake, B., Nilsson, C., and Sundelin, J. Structure and expression of the murine thromboxane A2 receptor gene. Biochem. Biophys. Res. Commun. 256(2), 391-397 (1999).

    8. Mais, D.E., True, T.A., and Martinelli, M.J. Characterization by photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 receptor: Evidence for N-linked glycosylation. Eur. J. Pharmacol. 227(3), 267-274 (1992).

    9. Takahashi, N., Takeuchi, K., Abe, T., et al. Immunolocalization of rat thromboxane receptor in the kidney. Endocrinology 137(11), 5170-5173 (1996).

    10. Wang, G.-R., Zhu, Y., Halushka, P.V., et al. Mechanism of platelet inhibition by nitric oxide: In vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 95(9), 4888-4893 (1998).

    11. Habib, A., Fitzgerald, G.A., and Maclouf, J. Phosphorylation of the thromboxane receptor α, the predominant isoform expressed in human platelets. The Journal of Biological Chemisty 274(5), 2645-2651 (1999).