A blocker of voltage-gated Na+ channels
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Product Categories

Product Type

Biochemicals

Research Area

Neuroscience
Pain Research

CAY10568

Item No. 10012565

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trimethyl[(phenylcarbamoyl)methyl]-ammonium iodide
CAS Number
22913-17-3
Synonyms
  • Santinamide
Molecular Formula
C11H17N2O • I
Formula Weight
320.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 3 mg/mlPBS (pH 7.2): 0.5 mg/ml
SMILES
[I-].O=C(Nc1ccccc1)C[N+](C)(C)C
InChi Code
InChI=1S/C11H16N2O.HI/c1-13(2,3)9-11(14)12-10-7-5-4-6-8-10;/h4-8H,9H2,1-3H3;1H
InChi Key
CCPHDQUNJSJNQK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $41

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    25 mg

    $95

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    50 mg

    $178

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    100 mg

    $312

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    Product Description

    Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported.1 CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Binshtok, A.M., Bean, B.P., and Woolf, C.J. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature 449, 607-610 (2007).