A natural H2S donor
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Diallyl Trisulfide

Item No. 10012577

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
di-2-propen-1-yl trisulfide
CAS Number
2050-87-5
Synonyms
  • DATS
  • NSC 651936
Molecular Formula
C6H10S3
Formula Weight
178.3
Purity
≥95%
Formulation (Request formulation change)
A 100 mg/ml solution in acetone
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 5 mg/mlEthanol: 3 mg/ml
SMILES
C=CCSSSCC=C
InChi Code
InChI=1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2
InChi Key
UBAXRAHSPKWNCX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $43

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    50 mg

    $81

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    100 mg

    $152

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    250 mg

    $333

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    Cayman Chemical
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    Product Description

    Diallyl trisulfide (DATS) is an organic polysulfide compound found in garlic that acts as an H2S donor.1 It reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM)2 and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM).3 DATS suppresses the growth of PC-3 xenografts in vivo in mice4 and induces vascular smooth muscle relaxation.1 Garlic extracts also lower cholesterol and there is evidence that DATS can alter the expression of genes and inhibit enzymes that are relevant to cholesterol synthesis.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Benavides, G.A., Squadrito, G.L., Mills, R.W., et al. Hydrogen sulfide mediates the vasoactivity of garlic. Proc. Natl. Acad. Sci. USA 104(46), 17977-17982 (2007).

    2. Xiao, D., Choi, S., Johnson, D.E., et al. Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2. Oncogene 23(33), 5594-5606 (2004).

    3. Hosono, T., Fukao, T., Ogihara, J., et al. Diallyl trisulfide supresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of ß-tubulin. The Journal of Biological Chemisty 280(50), 41487-41493 (2005).

    4. Xiao, D., Lew, K.L., Kim, Y.A., et al. Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with bax and bak induction. Clin. Cancer Res. 12(22), 6836-6843 (2006).

    5. Zhou, Z., Tan, H.L., Xu, B.X., et al. Microarray analysis of altered gene expression in diallyl trisulfide-treated HepG2 cells. Pharmacol. Rep. 57, 818-823 (2005).

    6. Gupta, N., and Porter, T.D. Garlic and garlic-derived compounds inhibit human squalene monooxygenase. J. Nutr. 131(6), 1662-1667 (2001).

    Product Citations

    Zhou, Y., Mazur, F., Liang, K., et al. Sensitivity and selectivity analysis of fluorescent probes for hydrogen sulfide detection. Chem. Asian J. 17(5), e202101399 (2022).