A natural H2S donor
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Diallyl Disulfide

Item No. 10012582

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
di-2-propen-1-yl-disulfide
CAS Number
2179-57-9
Synonyms
  • DADS
  • Garlicin
  • NSC 29228
Molecular Formula
C6H10S2
Formula Weight
146.3
Purity
≥80%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 5 mg/mlEthanol: 3 mg/ml
SMILES
C=CCSSCC=C
InChi Code
InChI=1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2
InChi Key
PFRGXCVKLLPLIP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    100 mg

    $26

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    500 mg

    $63

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    1 g

    $98

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    Product Description

    Diallyl disulfide (DADS) is an organosulfur compound derived from allicin, a natural compound found in garlic and related plants. DADS has diverse physiological effects, many that are cardio- and neuro-protective.1,2,3 These effects are due, at least in part because DADS is converted, in the presence of thiols, to the gaseous mediator hydrogen sulfide (H2S).1 Thus, DADS serves as a thiol-dependent H2S donor in biological systems.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Benavides, G.A., Squadrito, G.L., Mills, R.W., et al. Hydrogen sulfide mediates the vasoactivity of garlic. Proc. Natl. Acad. Sci. USA 104(46), 17977-17982 (2007).

    2. Xiao, D., Choi, S., Johnson, D.E., et al. Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2. Oncogene 23(33), 5594-5606 (2004).

    3. Gupta, N., and Porter, T.D. Garlic and garlic-derived compounds inhibit human squalene monooxygenase. J. Nutr. 131(6), 1662-1667 (2001).