An inhibitor of Nav1.8 channels
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

A-803467

Item No. 10012588

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
CAS Number
944261-79-4
Molecular Formula
C19H16ClNO4
Formula Weight
357.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 2.5 mg/ml
λmax
319 nm
SMILES
COc1cc(OC)cc(c1)NC(=O)c1ccc(o1)c1ccc(Cl)cc1
InChi Code
InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
InChi Key
VHKBTPQDHDSBSP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $41

    Add

    10 mg

    $75

    Add

    50 mg

    $312

    Add

    100 mg

    $544

    Add
    Product Description

    A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1.8 sodium channels (IC50 = 8 nM when stimulated at half-maximal inactivation and IC50 = 79 nM at a resting state).1 This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train.2 A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jarvis, M.F., Honore, P., Shieh, C.-C., et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc. Natl. Acad. Sci. USA 104(20), 8520-8525 (2007).

    2. Krafte, D.S., Chapman, M., Marron, B., et al. Block of NAv1.8 by small molecules. Channels (Austin) 1(3), 152-153 (2007).