An Analytical Reference Standard
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Labeled Version(s)
25426Lacosamide-d3
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Lacosamide

Item No. 10012592

Restricted Product (Schedule V)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • ADD 243037
  • Harkoseride
  • SPM 927
Technical Information
Formal Name
2R-(acetylamino)-3-methoxy-N-(phenylmethyl)-propanamide
CAS Number
175481-36-4
Molecular Formula
C13H18N2O3
Formula Weight
250.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
COC[C@@H](NC(=O)C)C(=O)NCc1ccccc1
InChi Code
InChI=1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1
InChi Key
VPPJLAIAVCUEMN-GFCCVEGCSA-N
Regulatory Information
DEA Schedule
V
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    Lacosamide (Item No. 10012592) is an analytical reference standard categorized as an anticonvulsant.1,2,3 Formulations containing lacosamide have been used in the treatment of partial-onset and tonic-clonic seizures. Lacosamide is regulated as a Schedule V compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Luszczki, J.J. Third-generation antiepileptic drugs: Mechanisms of action, pharmacokinetics and interactions. Pharmacol. Rep. 61(2), 197-216 (2009).

    2. Brandt, C., Heile, A., Potschka, H., et al. Effects of the novel antiepileptic drug lacosamide on the dvelopment of amygdala kindling in rats. Epilepsia 47(11), (2006).

    3. Stöhr, T., Kupferberg, H.J., Stables, J.P., et al. Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. Epilepsy Res. 74(2-3), 147-154 (2007).

    Product Citations

    Granit, A., Tetro, N., Shmuel, M., et al. Lacosamide at therapeutic concentrations induces histone hyperacetylation in vitro. Epilepsia Open 3(4), 535-539 (2018).

    Wang, Y., Brittain, J.M., Jarecki, B.W., et al. In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation. The Journal of Biological Chemisty 285(33), 25296-25307 (2010).