A novel inhibitor of HIF1α protein accumulation and transcription
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CAY10585

Item No. 10012682

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]-benzoic acid, methyl ester
CAS Number
934593-90-5
Synonyms
  • Hypoxia-Inducible Factor-1α Inhibitor
Molecular Formula
C26H29NO5
Formula Weight
435.5
Purity
≥97%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/ml
λmax
234, 260 nm
SMILES
O=C(NC1=CC(C(OC)=O)=CC=C1O)COC2=CC=C(C3(C[C@@H](C4)C5)C[C@H]5CC4C3)C=C2
InChi Code
InChI=1S/C26H29NO5/c1-31-25(30)19-2-7-23(28)22(11-19)27-24(29)15-32-21-5-3-20(4-6-21)26-12-16-8-17(13-26)10-18(9-16)14-26/h2-7,11,16-18,28H,8-10,12-15H2,1H3,(H,27,29)/t16-,17-,18?,26?/m1/s1
InChi Key
BJRPPNOJYFZSLY-DVYMTOFQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    CAY10585 is a novel small molecule inhibitor of HIF-1α accumulation and gene transcriptional activity.1 In a gene reporter assay using human Hep3B and AGS cell lines, CAY10585 prevented HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 µM, respectively. It blocks HIF-1α accumulation in Hep3B cells in a concentration and time-dependent manner, with complete inhibition at a concentration of 30 µM within 12 hours. CAY10585 also significantly suppresses transcription of the HIF-1 target genes VEGF and erythropoietin at 10 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, K., Lee, J.H., Boovanahalli, S.K., et al. (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors. J. Med. Chem. 50, 1675-1684 (2007).

    Product Citations

    Gupta, S.S., Sharp, R., Hofferek, C., et al. NIX-mediated mitophagy promotes effector memory formation in antigen-specific CD8+ T cells. Cell. Rep. 29(7), 1862-1877 (2019).