An Hsp90 inhibitor
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NVP-AUY922

Item No. 10012698

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide
CAS Number
747412-49-3
Synonyms
  • VER 52296
Molecular Formula
C26H31N3O5
Formula Weight
465.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlEthanol: 14 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
310 nm
SMILES
OC1=CC(O)=C(C(C)C)C=C1C2=C(C3=CC=C(CN4CCOCC4)C=C3)C(C(NCC)=O)=NO2
InChi Code
InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)
InChi Key
NDAZATDQFDPQBD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $169

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    10 mg

    $268

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    Cayman Chemical
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    Product Description

    NVP-AUY922 is a Hsp90 inhibitor (IC50 = 21 nM in a FP binding assay) that prevents the proliferation of a range of human cancer cell lines in vitro with GI50s averaging 9 nM.1 In a human colon cancer xenograft model, 50 mg/kg NVP-AUY922 inhibits tumor growth by ~50% compared to vehicle controls.1 Unlike some first generation Hsp90 inhibitors that are quickly glucuronidated, NVP-AUY922 is retained in tumors in vivo when administered at 4 mg/kg i.p. by cassette dosing in tumor-bearing mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brough, P.A., Aherne, W., Barril, X., et al. 4,5-diarylisoxazole Hsp90 chaperone inhibitors: Potential therapeutic agents for the treatment of cancer. J. Med. Chem. 51(2), 196-218 (2008).