A metal-chelating antimicrobial agent
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Clioquinol

Item No. 10021

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-7-iodo-8-quinolinol
CAS Number
130-26-7
Synonyms
  • Iodochlorohydroxyquin
  • NSC 3531
  • NSC 74938
Molecular Formula
C9H5ClINO
Formula Weight
305.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:8): 0.5 mg/ml
λmax
255, 324 nm
SMILES
OC1=C2C(C=CC=N2)=C(Cl)C=C1I
InChi Code
InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChi Key
QCDFBFJGMNKBDO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $28

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    10 mg

    $42

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    50 mg

    $154

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    250 mg

    $205

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    Cayman Chemical
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    Product Description

    Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.1,2,3 It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively.1 Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson's disease.2 It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ben Yaakov, D., Shadkchan, Y., Albert, N., et al. The quinoline bromoquinol exhibits broad-spectrum antifungal activity and induces oxidative stress and apoptosis in Aspergillus fumigatus. J. Antimicrob. Chemother. 72(8), 2263-2272 (2017).

    2. Finkelstein, D.I., Hare, D.J., Billings, J.L., et al. Clioquinol improves cognitive, motor function, and microanatomy of the α-Synuclein hA53T transgenic mice. ACS Chem. Neurosci. 7(1), 119-129 (2016).

    3. Lei, P., Ayton, S., Appukuttan, A.T., et al. Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse. Neurobiol. Dis. 81, 168-175 (2015).