Novel dietary CNS dopamine enhancing lipid
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N-(α-Linolenoyl) Tyrosine

Item No. 10032

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(9Z,12Z,15Z)-1-oxo-9,12,15-octadecatrien-1-yl]-L-tyrosine
CAS Number
259143-19-6
Synonyms
  • NALT
Molecular Formula
C27H39NO4
Formula Weight
441.6
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
226, 278 nm
SMILES
CC/C=C\C/C=C\C/C=C\CCCCCCCC(N([C@H](C(O)=O)CC1=CC=C(O)C=C1)[H])=O
InChi Code
InChI=1S/C27H39NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-26(30)28-25(27(31)32)22-23-18-20-24(29)21-19-23/h3-4,6-7,9-10,18-21,25,29H,2,5,8,11-17,22H2,1H3,(H,28,30)(H,31,32)/b4-3-,7-6-,10-9-
InChi Key
DEQLZTQITSWABQ-PDBXOOCHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $79

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    10 mg

    $147

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    50 mg

    $610

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    100 mg

    $1,065

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    Product Description

    Certain chronic neurologic disorders, such as Parkinson’s disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons.1 N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier.2 In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson’s therapeutic agent.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martin, J.B. Molecular basis of the neurodegenerative disorders. N. Engl. J. Med. 340(25), 1970-1980 (1999).

    2. Yehuda, S. Possible anti-Parkinson properties of N-(α-linolenoyl) tyrosine: A new molecule. Pharmacol. Biochem. Behav. 72(1-2), 7-11 (2002).