An isoprostane
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

8-iso Prostaglandin A1

Item No. 10035

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(8β)-15S-hydroxy-9-oxo-prosta-10,13E-dien-1-oic acid
CAS Number
211186-29-7
Synonyms
  • 8-epi PGA1
  • 8-iso PGA1
Molecular Formula
C20H32O4
Formula Weight
336.5
Purity
≥97%
Formulation
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 75 mg/mlDMSO: 50 mg/mlEthanol: 100 mg/mlPBS pH 7.2: 2.4 mg/ml
λmax
217 nm
SMILES
O=C1[C@@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C=C1
InChi Code
InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18-/m0/s1
InChi Key
BGKHCLZFGPIKKU-DRSVPBQLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 µg

    $40

    Add

    500 µg

    $129

    Add

    1 mg

    $217

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    8-iso Prostaglandin A1 (8-iso PGA1) is an isoprostane. It inhibits aldo-keto reductase family 1 member B10 (AKR1B10) in COS-7 lysates expressing the human enzyme when used at a concentration of 60 µM.1 8-iso PGA1 (0.1 µM) inhibits potassium-induced D-aspartate release from isolated bovine retinas.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Díaz-Dacal, B., Gayarre, J., Gharbi, S., et al. Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A1: Implications for antitumoral activity. Cancer Res. 71(12), 4161-4171 (2011).

    2. Opere, C.A., Zheng, W.D., Huang, J., et al. Dual effect of isoprostanes on the release of [3H]D-aspartate from isolated bovine retinae: Role of arachidonic acid metabolites. Neurochem. Res. 30(1), 129-137 (2005).

    Product Citations

    Opere, C.A., Zheng, W.D., Huang, J., et al. Dual effect of isoprostanes on the release of [3H]D-aspartate from isolated bovine retinae: Role of arachidonic acid metabolites. Neurochem. Res. 30(1), 129-137 (2005).