An isoprostane
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8-iso Prostaglandin A1

Item No. 10035

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(8β)-15S-hydroxy-9-oxo-prosta-10,13E-dien-1-oic acid
CAS Number
211186-29-7
Synonyms
  • 8-epi PGA1
  • 8-iso PGA1
Molecular Formula
C20H32O4
Formula Weight
336.5
Purity
≥97%
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 75 mg/mlDMSO: 50 mg/mlEthanol: 100 mg/mlPBS pH 7.2: 2.4 mg/ml
λmax
217 nm
SMILES
O=C1[C@@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C=C1
InChi Code
InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18-/m0/s1
InChi Key
BGKHCLZFGPIKKU-DRSVPBQLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    8-iso Prostaglandin A1 (8-iso PGA1) is an isoprostane. It inhibits aldo-keto reductase family 1 member B10 (AKR1B10) in COS-7 lysates expressing the human enzyme when used at a concentration of 60 µM.1 8-iso PGA1 (0.1 µM) inhibits potassium-induced D-aspartate release from isolated bovine retinas.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Díaz-Dacal, B., Gayarre, J., Gharbi, S., et al. Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A1: Implications for antitumoral activity. Cancer Res. 71(12), 4161-4171 (2011).

    2. Opere, C.A., Zheng, W.D., Huang, J., et al. Dual effect of isoprostanes on the release of [3H]D-aspartate from isolated bovine retinae: Role of arachidonic acid metabolites. Neurochem. Res. 30(1), 129-137 (2005).

    Product Citations

    Opere, C.A., Zheng, W.D., Huang, J., et al. Dual effect of isoprostanes on the release of [3H]D-aspartate from isolated bovine retinae: Role of arachidonic acid metabolites. Neurochem. Res. 30(1), 129-137 (2005).