A non-apoptotic, selective COX-2 inhibitor
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CAY10452

Item No. 10075

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
CAS Number
170569-87-6
Synonyms
  • PTPBS
Molecular Formula
C16H12F3N3O2S
Formula Weight
367.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:8): 0.1 mg/ml
λmax
203, 253 nm
SMILES
FC(F)(F)C1=NN(C2=CC=C(S(=O)(N)=O)C=C2)C(C3=CC=CC=C3)=C1
InChi Code
InChI=1S/C16H12F3N3O2S/c17-16(18,19)15-10-14(11-4-2-1-3-5-11)22(21-15)12-6-8-13(9-7-12)25(20,23)24/h1-10H,(H2,20,23,24)
InChi Key
MQPLMBSDWYIIID-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Product Description

    Inhibitors of cyclooxygenase (COX) are generally grouped according to selectivity for COX-1 versus COX-2.1,2 However, many COX inhibitors also show an antitumor, pro-apoptotic activity that is distinct from COX inhibition - celecoxib is an example.3 CAY10452 is a celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM), but does not induce apoptosis in prostate cancer cell lines even at 100 µM.4 CAY10452 is thus a clean, selective tool for the inhibition of COX-2.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khanna, I.K., Yu, Y., Huff, R.M., et al. Selective cyclooxygenase-2 inhibitors: Heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents. J. Med. Chem. 43(16), 3168-3185 (2000).

    2. FitzGerald, G.A., and Loll, P. COX in a crystal ball: Current status and future promise of prostaglandin research. J. Clin. Invest. 107(11), 1335-1337 (2001).

    3. Dempke, W., Rie, C., Grothey, A., et al. Cyclooxygenase-2: A novel target for cancer chemotherapy? J. Cancer Res. Clin. Oncol. 127(7), 411-417 (2001).

    4. Song, X., Lin, H.P., Johnson, A.J., et al. Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells. J. Natl. Cancer Inst. 94(8), 585-591 (2002).