An inhibitor of HSV and HIV-1 viral replication
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16,16-dimethyl Prostaglandin A1

Item No. 10080

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
15R-hydroxy-16,16-dimethyl-9-oxo-prosta-10,13E-dien-1-oic acid
CAS Number
41692-24-4
Synonyms
  • 16,16-dimethyl PGA1
Molecular Formula
C22H36O4
Formula Weight
364.5
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >75 mg/mlDMSO: >50 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): >2.4 mg/ml
λmax
216 nm
SMILES
O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)C=C1
InChi Code
InChI=1S/C22H36O4/c1-4-5-16-22(2,3)20(24)15-13-17-12-14-19(23)18(17)10-8-6-7-9-11-21(25)26/h12-15,17-18,20,24H,4-11,16H2,1-3H3,(H,25,26)/b15-13+/t17-,18-,20-/m1/s1
InChi Key
CTQQHQGBBMYJPT-DZFVFWAGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    16,16-dimethyl Prostaglandin A1 (16,16-dimethyl PGA1) is a metabolism resistant analog of PGA1. In vitro, it inhibits the viral replication in both HSV and HIV-1 infection systems at concentrations that do not adversely alter cellular DNA synthesis. The ID50 for HSV-1 strains in Vero cells and human foreskin fibroblasts are 3.8-5.6 µg/ml and 4.6-7.3 µg/ml, respectively. The ID50 for T cells acutely infected with HIV-1 is 2.5 µg/ml.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hughes-Fulford, M., McGrath, M.S., Hanks, D., et al. Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. Antimicrob. Agents Chemother. 36(10), 2253-2258 (1992).