A selective COX-2 inhibitor
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Etoricoxib

Item No. 10091

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine
CAS Number
202409-33-4
Synonyms
  • L-791,456
  • MK-0663
Molecular Formula
C18H15ClN2O2S
Formula Weight
358.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: freelyMethanol: freely
λmax
236, 285 nm
SMILES
ClC1=CN=C(C2=CN=C(C)C=C2)C(C3=CC=C(S(C)(=O)=O)C=C3)=C1
InChi Code
InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3
InChi Key
MNJVRJDLRVPLFE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    50 mg

    $135

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    100 mg

    $219

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    250 mg

    $502

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    Product Description

    Etoricoxib is a dipyridinyl compound that demonstrates high in vitro and ex vivo selectivity for COX-2 over COX-1 in several assays, e.g., in the production of PGE2 by CHO cells expressing either COX-2 (IC50 = 79 nM) or COX-1 (IC50 > 50 µM).1,2 Oral etoricoxib is well absorbed and metabolized extensively via oxidation, with metabolites excreted largely in the urine.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Riendeau, D., Percival, M.D., Brideau, C., et al. Etoricoxib (MK-0663): Preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J. Pharmacol. Exp. Ther. 296, 558-566 (2001).

    2. Dallob, A., Hawkey, C.J., Greenberg, H., et al. Characterization of etoricoxib, a novel, selective COX-2 inhibitor. J. Clin. Pharmacol. 43(6), 573-585 (2003).

    3. Rodrigues, A.D., Halpin, R.A., Geer, L.A., et al. Absorption, metabolism, and exceretion of ethoricoxib, a potent and selective cyclooxygenase-2 inhibitor, in healthy male volunteers. Drug Metab. Dispos. 31(2), 224-232 (2003).