A Δ5/Δ6 desaturase inhibitor
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CP 24,879 (hydrochloride)

Item No. 10120

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(3-methylbutoxy)-benzenamine, monohydrochloride
CAS Number
10141-51-2
Synonyms
  • p-(Isopentyloxy)-aniline
Molecular Formula
C11H17NO • HCl
Formula Weight
215.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 50 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.5 mg/ml
λmax
275 nm
SMILES
NC1=CC=C(C=C1)OCCC(C)C.Cl
InChi Code
InChI=1S/C11H17NO.ClH/c1-9(2)7-8-13-11-5-3-10(12)4-6-11;/h3-6,9H,7-8,12H2,1-2H3;1H
InChi Key
GFESZSNFRSACMU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $150

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    10 mg

    $264

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    25 mg

    $616

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    Product Description

    Essential fatty acid deficiency symptoms include immune system depression and a general state of inflammatory inhibition. CP 24,879 is an inhibitor of arachidonic acid biosynthesis acting via the inhibition of Δ5/Δ6 desaturase.1 Mice injected with CP 24,879 at 3 mg/kg had a reduction of liver arachidonate content of approximately 50%. Murine mastocytoma cells treated with 5 µM CP 24,879 showed increased mead acid content and nearly complete ablation of leukotriene C4 synthesis, consistent with a desaturase inhibition-induced state of essential fatty acid deficiency.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Obukowicz, M.G., Raz, A., Pyla, P.D., et al. Identification and characterization of a novel Δ6/Δ5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochem. Pharmacol. 55(7), 1045-1058 (1998).

    2. Levin, G., Duffin, K.L., Obukowicz, M.G., et al. Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem. J. 365(Pt 2), 489-496 (2002).