For immunochemical detection of the DP1 receptor
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DP1 Receptor Polyclonal Antibody

Item No. 101640

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PGD2 Receptor
  • Prostaglandin D2 Receptor
Immunogen
Peptide from the N-terminal region of mouse DP1 receptor
MW
~41 kDa
Formulation (Request formulation change)
500 µl of peptide-affinity purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol, and 0.02% sodium azide
Host
Rabbit
Applications
IF, WB
Cross Reactivity
(+) DP1 receptor
Species Reactivity
(+) Human(+) Mouse(+) Rat
UniProt Accession №
P70263
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    Prostaglandin D2 (PGD2) binds to two receptor subtypes: DP1 and CRTH2/DP2, which are both membrane-bound G protein-coupled receptors (GPCRs) but do not have significant homology and are differentially expressed.1 The DP1 receptor is expressed in various tissues and cells including the brain, spleen, lungs, bone marrow, stomach, skin, and mast cells.2,3,4 It is coupled to Gαs, and its activation increases intracellular cAMP levels.5 Signaling through the DP1 receptor is involved in inflammation, allergy, and sleep regulation.5,1 Cayman’s DP1 Receptor Polyclonal Antibody can be used for immunofluorescence (IF) and Western blot (WB) applications. The antibody recognizes the DP1 receptor at approximately 41 kDa from human, mouse, and rat samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ahmad, A.S., Ottallah, H., Maciel, C.B., et al. Role of the L-PGDS-PGD2-DP1 receptor axis in sleep regulation and neurologic outcomes. Sleep 42(6), zsz073 (2019).

    2. Hirata, M., Kakizuka, A., Aizawa, M., et al. Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. Proc. Natl. Acad. Sci. USA 91, 11192-11196 (1994).

    3. Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. The Journal of Biological Chemisty 270(32), 18910-18916 (1995).

    4. Narumiya, S., Sugimoto, Y., and Ushikubi, F. Prostanoid receptors: Structures, properties, and functions. Physiol. Rev. 79(4), 1193-1226 (1999).

    5. Kabashima, K., and Narumiya, S. The DP receptor, allergic inflammation and asthma. Prostaglandins Leukot. Essent. Fatty Acids 69(2-3), 187-194 (2003).

    Product Citations

    Catalano, R.D., Wilson, M.R., Boddy, S.C., et al. Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle. mol. Hum. Reprod. 17(3), 182-192 (2011).