For immunochemical detection of the EP1 receptor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

EP1 Receptor Polyclonal Antibody

Item No. 101740

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PGE2 Receptor 1
  • Prostaglandin E2 Receptor 1
Immunogen
Synthetic peptide from the C-terminal region of human EP1
Formulation (Request formulation change)
500 µl peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
IF, IHC, and WB
Cross Reactivity
(-) EP2 receptor(-) EP3 receptor(-) EP4 receptor
Species Reactivity
(+) Human(+) Mouse(+) Rat
UniProt Accession №
P34995
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 ea (500 µl)

    $347

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    The biological effects of PGE2 are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP1, EP2, EP3, and EP4.1,2 Binding of PGE2 to the EP1 receptor results in an increase in phosphatidyl inositol turnover with subsequent increase in intracellular free Ca2+.3,4 Pharmacologically, EP1 receptors mediate contraction of smooth muscle.1 The human EP1 receptor is comprised of 402 amino acids with a molecular mass of approximately 42,000.3 The EP1 receptor is expressed in a variety of tissues, including the kidney, lung, and sensory neuron.3,4,5 Within the kidney, the EP1 receptor is expressed at high levels in the cortical, outer medullary, and inner medullary collecting duct.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Coleman, R.A., Smith, W.L., and Narumiya, S. International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46(2), 205-229 (1994).

    2. Coleman, R.A., Eglen, R.M., Jones, R.L., et al. Classification of prostanoid receptors IUPHAR receptor compendium. IUPHAR Compendium 1-12 (1997).

    3. Funk, C.D., Furci, L., Fitzgerald, G.A., et al. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. The Journal of Biological Chemisty 268(35), 26767-26772 (1993).

    4. Honda, A., Sugimoto, Y., Namba, T., et al. Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype. The Journal of Biological Chemisty 268, 7759-7762 (1993).

    5. Southall, M.D., and Vasko, M.R. Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons. The Journal of Biological Chemisty 276(19), 16083-16091 (2001).

    6. Breyer, M.D., Davis, L., Jacobson, H.R., et al. Differential localization of prostaglandin E receptor subtypes in human kidney. Am. J. Physiol. 270, F912-F918 (1996).

    Product Citations

    Minhas, P.S., Latif-Hernandez, A., McReynolds, M.R., et al. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature (2021).

    Nirmal, J., Tyagi, P., Chuang, Y.-C., et al. Functional and molecular characterization of hyposensitive underactive bladder tissue and urine in streptozotocin-induced diabetic rat. PloS One 9(7), e102644 (2014).

    Catalano, R.D., Wilson, M.R., Boddy, S.C., et al. Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle. mol. Hum. Reprod. 17(3), 182-192 (2011).

    Roca-Ferrer, J., Garcia-Garcia, F.J., Pereda, J., et al. Reduced expression of COXs and production of prostaglandin E2 in patients with nasal polyps with or without aspirin-intolerant asthma. J. Allergy Clin. Immunol. 128, 66-72 (2011).

    George, R.J., Sturmoski, M.A., Anant, S., et al. EP4 mediates PGE2 dependent cell survival through the PI3 kinase/AKT pathway. Prostaglandins Other Lipid Mediat. 83(1-2), 112-120 (2007).