For immunochemical detection of the EP3 receptor
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Applicable for Use with
301760EP3 Receptor Blocking Peptide
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EP3 Receptor Polyclonal Antibody

Item No. 101760

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PGE2 Receptor 3
  • Prostaglandin E2 Receptor 3
Immunogen
Synthetic peptide from an internal region of human EP3 receptor
Formulation (Request formulation change)
500 µl of peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 0.02% sodium azide and 50% glycerol
Host
Rabbit
Applications
ICC, IHC, and WB
Cross Reactivity
(+) EP3 receptor(-) EP1 receptor(-) EP2 receptor(-) EP4 receptor
Species Reactivity
(+) Human(+) Bovine(+) Mouse(+) Rat
UniProt Accession №
P43115
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    The biological effects of prostaglandin E2 (PGE2) are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP1, EP2, EP3, and EP4.1,2 As a result of splice variation, the EP3 receptor can be expressed as multiple isoforms that differ in the length and sequence of their C-terminal tails.2,3 The signal transduction mechanism varies depending on the isoform being expressed, implicating the importance of the C-terminal region of the receptor for coupling to G-proteins.2,3 The EP3 receptor is expressed in a variety of tissues with highest levels in kidney, pancreas, and uterus.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Coleman, R.A., Eglen, R.M., Jones, R.L., et al. Classification of prostanoid receptors IUPHAR receptor compendium. IUPHAR Compendium 1-12 (1997).

    2. Narumiya, S., Sugimoto, Y., and Ushikubi, F. Prostanoid receptors: Structures, properties, and functions. Physiol. Rev. 79(4), 1193-1226 (1999).

    3. Kotani, M., Tanaka, I., Ogawa, Y., et al. Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: Multiple second messenger systems and tissue-specific distributions. Mol. Pharmacol. 48, 869-879 (1995).

    4. Sugimoto, Y., Namba, T., Honda, A., et al. Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype. The Journal of Biological Chemisty 267, 6463-6466 (1992).

    5. Yang, J., Xia, M., Goetzl, E.J., et al. Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2. Biochem. Biophys. Res. Commun. 198, 999-1006 (1994).

    Product Citations

    Minhas, P.S., Latif-Hernandez, A., McReynolds, M.R., et al. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature (2021).

    Nirmal, J., Tyagi, P., Chuang, Y.-C., et al. Functional and molecular characterization of hyposensitive underactive bladder tissue and urine in streptozotocin-induced diabetic rat. PloS One 9(7), e102644 (2014).

    Roca-Ferrer, J., Garcia-Garcia, F.J., Pereda, J., et al. Reduced expression of COXs and production of prostaglandin E2 in patients with nasal polyps with or without aspirin-intolerant asthma. J. Allergy Clin. Immunol. 128, 66-72 (2011).

    George, R.J., Sturmoski, M.A., Anant, S., et al. EP4 mediates PGE2 dependent cell survival through the PI3 kinase/AKT pathway. Prostaglandins Other Lipid Mediat. 83(1-2), 112-120 (2007).