For immunochemical detection of the FP receptor
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FP Receptor Polyclonal Antibody

Item No. 101802

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PGF2α Receptor
  • Prostaglandin F2α Receptor
Immunogen
Synthetic peptide from the N-terminal cytoplasmic region of mouse protein FP receptor
Formulation (Request formulation change)
Peptide-affinity purified antibody lyophilized from 500 µl
Storage Buffer
TBS, pH 7.4, with 0.5% BSA when reconstituted in 500 μl deionized water
Host
Rabbit
Isotype
IgG
Applications
WB
Species Reactivity
(+) Human(+) Bovine(+) Mouse(+) Ovine(+) Rat
UniProt Accession №
P43117
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    The prostaglandin F2α receptor (FP receptor) is a G protein-coupled receptor known to elicit smooth muscle contraction in a variety of tissues.1 FP receptor mRNA is found in reproductive, gastric, neural, and ocular tissues as well as specialized cells of the kidney.2,3,4,5 Two FP receptor isoforms, FPA and FPB have been identified in sheep.6 FPB receptor is truncated at the carboxy-terminus thereby preventing desensitization (which normally occurs by protein kinase C phosphorylation of FPA) and produces aberrant signalling in FPB transfectants.7,8 The existence of a truncated human FP isoform responsible for signal-amplification contributing to luteolysis, cell growth, or malignant transformation is currently unknown.6,7,8,9 Cayman’s FP Receptor Polyclonal Antibody can be used for Western blot applications. The calculated size of FP Receptor is 41 kDa and this antibody recognizes multiple bands from 50-67 kDa from human, bovine, mouse, ovine, and rat samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Narumiya, S., Sugimoto, Y., and Ushikubi, F. Prostanoid receptors: Structures, properties, and functions. Physiol. Rev. 79(4), 1193-1226 (1999).

    2. Abramovitz, M., Boie, Y., Nguyen, T., et al. Cloning and expression of a cDNA for the human prostanoid FP receptor. The Journal of Biological Chemisty 269(4), 2632-2636 (1994).

    3. Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Lett. 355(3), 317-325 (1994).

    4. Kitanaka, J., Hasimoto, H., Sugimoto, Y., et al. Cloning and expression of a cDNA for rat prostaglandin F2α receptor. Prostaglandins 48, 31-41 (1994).

    5. Mukhopadhyay, P., Bian, L., Yin, H., et al. Localization of EP1 and FP receptors in human ocular tissues by in situ hybridization. Invest. Ophthalmol. Vis. Sci. 42(2), 424-428 (2001).

    6. Pierce, K.L., Bailey, T.J., Hoyer, P.B., et al. Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor. The Journal of Biological Chemisty 272(2), 883-887 (1997).

    7. Fujino, H., Srinivasan, D., Pierce, K.L., et al. Differential regulation of prostaglandin F2α receptor isoforms by protein kinase C. Mol. Pharmacol. 57, 353-358 (2000).

    8. Fujino, H., and Regan, J.W. FP prostanoid receptor activation of a T-cell factor/β-catenin signaling pathway. The Journal of Biological Chemisty 276(16), 12489-12492 (2001).

    9. Sugimoto, Y., Yamasaki, A., Segi, E., et al. Failure of parturition in mice lacking the prostaglandin F receptor. Science 277, 681-683 (1997).