For immunochemical detection of cPGES
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Prostaglandin E Synthase (cytosolic, FL) Polyclonal Antibody

Item No. 10209

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • cPGES
  • cPGE Synthase
  • Hsp90 Co-chaperone
  • p23
  • Teolomerate-binding protein p23
Immunogen
Full-length, human recombinant cytosolic prostaglandin E synthase
Formulation (Request formulation change)
500 µl of Protein A-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
WB, ICC
Cross Reactivity
(-) Microsomal PGES-1(-) Microsomal PGES-2
Species Reactivity
(+) Human cPGES
UniProt Accession №
Q15185
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µl

    $347

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    Product Description

    Cytosolic PGE synthase (cPGES) is a glutathione-dependent enzyme with a predicted size of 18.6 kDa (23 kDa on SDS-PAGE). The enzyme is expressed in a wide variety of tissues and cells, the levels of which are unaffected by treatment with IL-1β and TNFα.1 However, enzyme expression increases approximately 3-fold in rat brain following LPS treatment.1 Microsomal PGE synthase (mPGES) is a 16 kDa protein expressed in a variety of tissues.2 In contrast to cPGES, mPGES protein expression is increases in A549 cells following treatment with IL-1β.2 The two enzymes show <10% homology at the amino acid level.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tanioka, T., Nakatani, Y., Semmyo, N., et al. Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 immediate prostaglandin E2 biosynthesis. The Journal of Biological Chemisty 275, 32775-32782 (2000).

    2. Jakobsson, P.J., Thorén, S., Morgenstern, R., et al. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. USA 96(13), 7220-7225 (1999).

    Product Citations

    Liu, C.H., Chang, S.H., Narko, K., et al. Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. The Journal of Biological Chemisty 276(21), 18563-18569 (2001).