An MAGL and FAAH inhibitor
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IDFP

Item No. 10215

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-dodecyl-phosphonofluoridic acid, 1-methylethyl ester
CAS Number
615250-02-7
Synonyms
  • Isopropyl Dodecylfluorophosphonate
Molecular Formula
C15H32FO2P
Formula Weight
294.4
Purity
≥98%
Formulation
A 5 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 12 mg/mlEthanol: 10 mg/ml
SMILES
CCCCCCCCCCCCP(=O)(F)OC(C)C
InChi Code
InChI=1S/C15H32FO2P/c1-4-5-6-7-8-9-10-11-12-13-14-19(16,17)18-15(2)3/h15H,4-14H2,1-3H3
InChi Key
SFRALHFBKRAJPW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $63

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    1 mg

    $118

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    5 mg

    $481

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    10 mg

    $842

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    Product Description

    The endocannabinoids, 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA), are biologically active lipids that regulate diverse neurological and metabolic functions by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2). Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) hydrolyze 2-AG and AEA, respectively, thus terminating their biological function. IDFP is an organophosphorus compound that dually inhibits MAGL and FAAH with IC50 values of 0.8 and 3 nM, respectively.1 At 10 mg/kg, IDFP elevates brain levels of 2-AG and AEA more than 10-fold, and decreases levels of arachidonic acid by a similar magnitude.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nomura, D.K., Blankman, J.L., Simon, G.M., et al. Activation of the endocannabinoid system by organophosphorus nerve agents. Nat. Chem. Biol. 4(6), 373-378 (2008).