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Histone H4 (human, recombinant)

Item No. 10264

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • H4
  • Histone H4
Purity
≥75% estimated by SDS-PAGE
Source
Recombinant protein expressed in E. coli
Amino Acids
Amino acids 1-103 (full-length)
MW
11.5 kDa
Formulation (Request formulation change)
A solution in water (frozen)
UniProt Accession №
P62805
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $138

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    Product Description

    A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4.1 The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core.2 Histone H4 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bhaumik, S.R., Smith, E., and Shilatifard, A. Covalent modifications of histones during development and disease pathogenesis. Nat. Struct. Mol. Biol. 14(11), 1008-1016 (2007).

    2. Tanaka, Y., Tawaramoto-Sasanuma, M., Kawaguchi, S., et al. Expression and purification of recombinant human histones. Methods 33(1), 3-11 (2004).