A synthetic analog of PGA2
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15-deoxy-Δ12,14-Prostaglandin A2

Item No. 10265

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-oxo-prosta-5Z,10,12Z,14E-tetraen-1-oic acid
CAS Number
112839-31-3
Synonyms
  • 15-deoxy-Δ12,14-PGA2
Molecular Formula
C20H28O3
Formula Weight
316.4
Purity
≥98% (isomer mixture; major component is trans,trans-Δ12,14)
Formulation (Request formulation change)
A 5 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 75 mg/ml (from PGA1)DMSO: 50 mg/ml (from PGA1)Ethanol: 100 mg/ml (from PGA1)PBS pH 7.2: 2.4 mg/ml (from PGA1)
λmax
324 nm
SMILES
O=C1[C@H](C/C=C\CCCC(O)=O)/C(C=C1)=C\C=C\CCCCC
InChi Code
InChI=1S/C20H28O3/c1-2-3-4-5-6-9-12-17-15-16-19(21)18(17)13-10-7-8-11-14-20(22)23/h6-7,9-10,12,15-16,18H,2-5,8,11,13-14H2,1H3,(H,22,23)/b9-6+,10-7-,17-12-/t18-/m1/s1
InChi Key
BHHHGDAJJMEHST-NBIYZLHXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    5 mg

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    Product Description

    15-deoxy-Δ12,14-PGA2 is a synthetic analog of PGA2. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ.1,2 Antimitotic and antitumor activity have been reported for a similar analog,3 but there are no published reports on the biological activity of 15-deoxy-Δ12,14-PGA2 at this time.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83(5), 813-819 (1995).

    2. Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83(5), 803-812 (1995).

    3. Kato, T., Fukushima, M., Kurozumi, S., et al. Antitumor activity of Δ7-prostaglandin A1 and Δ12-prostaglandin J2 in vitro and in vivo. Cancer Res. 46(7), 3538-3542 (1986).