A hydrogen sulfide-releasing NSAID
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ATB-337

Item No. 10277

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester
CAS Number
912758-00-0
Synonyms
  • ACS 15
  • S-Diclofenac
Molecular Formula
C23H15NCl2O2S3
Formula Weight
504.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/ml
λmax
276, 319, 436 nm
SMILES
O=C(Oc1ccc(cc1)c1ssc(=S)c1)Cc1ccccc1Nc1c(Cl)cccc1Cl
InChi Code
InChI=1S/C23H15Cl2NO2S3/c24-17-5-3-6-18(25)23(17)26-19-7-2-1-4-15(19)12-21(27)28-16-10-8-14(9-11-16)20-13-22(29)31-30-20/h1-11,13,26H,12H2
InChi Key
BRDUXOHVEZVAHI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $174

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    10 mg

    $270

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    25 mg

    $434

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    Product Description

    ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac.1 In rats, diclofenac at 10-50 µmol/kg caused significant gastrointestinal damage, whereas no damage was observed with ATB-337 treatment at the same dose. ATB-337 at 50 µmol/kg does not promote leukocyte adherence to vascular endothelium, an effect observed with diclofenac treatment alone. COX-1 and COX-2 were inhibited with similar efficacy by diclofenac and ABT-337. An increase in expression of the pro-inflammatory mediator TNF-α, as well as, the adhesion molecules ICAM-1 and LFA-1 were not observed in rats treated with 50 µmol/kg ABT-337, effects seen with equimolar doses of diclofenac. These results indicate that H2S-releasing derivatives of NSAIDs may prove to be more effective anti-inflammatory agents than traditional NSAIDs alone.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wallace, J.L., Caliendo, G., Santagada, V., et al. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology 132, 261-271 (2007).