Active, pure human recombinant enzyme
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PAF Acetylhydrolase (human, recombinant)

Item No. 10279

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Group-VIIA phospholipase A2
  • LDL-PLA(2)
  • Lipoprotein PLA2
  • PAF-AH
  • PLA2G7
  • gVIIA-PLA2
  • Lp-PLA2
  • Platelet-activating Factor Acetylhydrolase
Purity
≥75% estimated by SDS-PAGE
Source
Active recombinant N-terminal hexahistidine-tagged protein expressed in E. coli
Amino Acids
42-441 (full-length)
MW
46.4 kDa
Formulation (Request formulation change)
50 mM sodium phosphate, pH 7.2, 100 mM NaCl, 10% glycerol
UniProt Accession №
Q13093
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $528

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    Product Description

    Platelet-activating factor (PAF) is an important lipid mediator involved in inflammation. PAF-acetylhydrolase (PAF-AH) is an extracellular phospholipase A2 which hydrolyzes the acetyl group at the sn-2 position of phospholipids.1 Two main types of PAF-AH have been characterized, namely the secreted (i.e. plasma) and intracellular enzymes, which are encoded on individual genes and share only 41% homology at the amino acid level.2,3 Cayman’s PAF-AH is the secreted calcium-independent isoform. PAF deacetylation by PAF-AH causes loss of biological activity, making PAF-AH potentially useful as an anti-inflammation therapy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tjoelker, L.W., Wilder, C., Eberhardt, C., et al. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 374(6522), 549-553 (1995).

    2. Stafforini, D.M., McIntyre, T.M., Zimmerman, G.A., et al. Platelet-activating factor acetylhydrolases. The Journal of Biological Chemisty 272(29), 17895-17898 (1997).

    3. Hattori, K., Adachi, H., Matsuzawa, A., et al. cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase. The Journal of Biological Chemisty 271(51), 33032-33038 (1996).