Active, pure human recombinant enzyme
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

SET7/9 (human recombinant)

Item No. 10320

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • KMT7
  • SETD7
  • SETD7/9
  • SET Domain-containing Protein 7/9
Purity
≥95% estimated by SDS-PAGE
Source
Active recombinant N-terminal His-tagged SET7/9 purified from E. coli
Amino Acids
1-366 (full-length)
MW
43.3 kDa
Formulation (Request formulation change)
50 mM HEPES, pH 7.2, 100 mM sodium chloride, and 20% glycerol
UniProt Accession №
Q8WTS6
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $662

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function.1 Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase.2 SET7/9 methylates histone H3, tumor suppressor p53, and transcription factor TAF10.3 Recently, SET7/9 was shown to catalyze methylation of p53 in response to DNA damage thereby activating p53 for subsequent acetylation.1 SET7/9 is able to modulate p53 activity in a human cancer cell line, implying that it may play a significant role in human tumorigenesis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kurash, J.K., Lei, H., Shen, Q., et al. Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol. Cell 29, 392-400 (2008).

    2. Xiao, B., Jing, C., Wilson, J.R., et al. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature 421, 652-656 (2003).

    3. Couture, J.F., Collazo, E., Hauk, G., et al. Structural basis for the methylation site specificity of SET7/9. Nat. Struct. Mol. Biol. 13(2), 140-146 (2006).