Substrate for acceptor peptide SET8
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Histone H4 Peptide Substrate (15-24)

Item No. 10380

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Histone H4K20 Peptide
  • SET8 Methyltransferase Acceptor Peptide
Formula Weight
1280.0
Formulation (Request formulation change)
A lyophilized peptide
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $84

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    5 mg

    $328

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    Product Description

    Histone H4 undergoes many modifications including acetylation, methylation, and phosphorylation, each important for regulation of gene transcription.1,2 This histone H4 peptide contains a lysine at position 20 which is a substrate or acceptor peptide for the lysine methyltransferases KMT5A (SET8) and KMT5B (SUV4-20H1).3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kouzarides, T. Chromatin modifications and their function. Cell 128(4), 693-705 (2007).

    2. Pennisi, E. Opening the way to gene activity. Science 275(5297), 155-157 (1997).

    3. Yin, Y., Liu, C., Tsai, S.N., et al. SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20. The Journal of Biological Chemisty 280(34), 30025-30031 (2005).

    4. Couture, J.F., Collazo, E., Brunzelle, J.S., et al. Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Genes Dev. 19(12), 1455-1465 (2005).